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Otitis media in a mouse model for Down syndrome.

Fengchan Han¹, Heping Yu, Jiangping Zhang

¹Department of Otolaryngology-HNS, Case Western Reserve University, Cleveland, OH 44106, USA.

International Journal of Experimental Pathology

|September 22, 2009

Summary

The Ts65Dn mouse model for Down syndrome frequently experiences otitis media, or middle ear infections, leading to hearing loss. This study identifies pathological changes and bacterial presence in these mice, highlighting their utility for Down syndrome research.

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Area of Science:

Genetics
Neuroscience
Otolaryngology

Background:

The Ts65Dn mouse is a widely used model for studying Down syndrome.
Down syndrome is associated with various health complications, but middle ear disease has not been extensively studied in this model.

Purpose of the Study:

To investigate the prevalence and characteristics of otitis media in Ts65Dn mice.
To assess hearing function and middle ear pathology in this Down syndrome model.

Main Methods:

Auditory-evoked brainstem response (ABR) testing was performed on Ts65Dn and wild-type mice.
Middle ear pathology was examined through direct observation and histological analysis.
Bacterial cultures were used to identify microorganisms in the middle ear effusion.

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Main Results:

81.1% of Ts65Dn mice exhibited elevated ABR thresholds, indicating hearing loss.
Middle ear effusion was significantly more common in Ts65Dn mice (11/15) compared to wild-type controls (2/11).
Histological examination revealed thickened middle ear mucosa and increased goblet cells in Ts65Dn mice, along with the presence of pathogenic bacteria.

Conclusions:

Otitis media is a prevalent condition in the Ts65Dn mouse model, mirroring aspects of human Down syndrome.
The Ts65Dn mouse serves as a valuable model for studying the mechanisms and potential treatments for otitis media in Down syndrome.