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Related Experiment Video

Updated: Jun 20, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

Glucose level and brain infarction: a prospective case-control study and prospective study.

M Mazighi1, J Labreuche, P Amarenco

  • 1INSERM U-698 and Denis Diderot University, Paris VII, France.

International Journal of Stroke : Official Journal of the International Stroke Society
|September 22, 2009
PubMed
Summary

Elevated blood glucose levels are linked to brain infarction in women and increased mortality. Further research is needed to optimize glucose management in stroke patients.

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Area of Science:

  • Neurology
  • Endocrinology
  • Public Health

Background:

  • Hyperglycaemia in acute stroke predicts higher mortality.
  • Recent studies question the benefit of active hyperglycaemia treatment in brain infarction.
  • Further data are needed to clarify the role of hyperglycaemia in stroke and identify at-risk patients.

Purpose of the Study:

  • To investigate the association between admission glucose levels and brain infarction.
  • To determine the impact of glucose levels on functional outcome and mortality after stroke.
  • To explore potential sex differences in the relationship between glucose and stroke.

Main Methods:

  • A case-control study involving 477 brain infarction patients and 395 controls.
  • Data collection included ECG, carotid ultrasonography, transcranial Doppler, and fasting glucose measurements.

Related Experiment Videos

Last Updated: Jun 20, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

  • Functional outcome assessed using the modified Rankin scale at multiple time points.

    • Main Results:

    • Higher adjusted mean glucose levels were observed in brain infarction patients compared to controls (6.4 vs. 6.0 mmol/l).
    • Elevated glucose was associated with brain infarction in women (OR 2.21) but not significantly in men (OR 1.02).
    • In infarction cases, elevated glucose correlated with poor outcomes and higher mortality, irrespective of sex.

    Conclusions:

    • Admission hyperglycaemia is associated with brain infarction in women and increased long-term mortality.
    • The findings highlight the need for further research into glucose management strategies for acute brain infarction.
    • Sex-specific analyses are crucial for understanding glycaemic impact in stroke patients.