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Updated: Jun 20, 2026
08:30
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
Circulating ADAMTS-13-von Willebrand factor complexes: an enzyme on demand
J T B Crawley1, R de Groot, B M Luken
1Department of Haematology, Imperial College London, London, UK. j.crawley@imperial.ac.uk
Journal of Thrombosis and Haemostasis : JTH
|September 22, 2009
Summary
No abstract available in PubMed .
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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
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