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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Published on: July 14, 2023

Cinacalcet in hyperfunctioning parathyroid diseases.

Yasuo Imanishi¹, Masaaki Inaba, Takehisa Kawata

¹Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. imanishi@med.osaka-cu.ac.jp

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|September 22, 2009

Summary

This summary is machine-generated.

Cinacalcet, a calcimimetic, enhances calcium-sensing receptor (CaR) sensitivity, effectively lowering parathyroid hormone (PTH) in secondary hyperparathyroidism. This review explores cinacalcet

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Area of Science:

Endocrinology
Nephrology
Pharmacology

Background:

The calcium-sensing receptor (CaR) regulates parathyroid hormone (PTH) secretion based on extracellular calcium levels.
Secondary hyperparathyroidism (SHPT) is common in uremic patients undergoing hemodialysis.
Cinacalcet is a positive allosteric modulator of CaR.

Purpose of the Study:

To review the mechanism of action of cinacalcet.
To postulate the beneficial effects of cinacalcet on hyperfunctioning parathyroid diseases based on experimental data.

Main Methods:

Review of basic experiments involving cinacalcet.
Analysis of cinacalcet's effect on CaR sensitivity and PTH secretion.

Main Results:

Cinacalcet increases CaR sensitivity to extracellular calcium.
Cinacalcet effectively suppresses PTH release.
Cinacalcet is an established treatment for SHPT in hemodialysis patients.

Conclusions:

Cinacalcet's mechanism involves enhancing CaR activation by calcium.
Cinacalcet demonstrates efficacy in managing SHPT.
Further exploration of cinacalcet's benefits in various hyperparathyroid conditions is warranted.