Related Experiment Video
Updated: Jun 20, 2026
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
Chronic kidney disease after hematopoietic cell transplantation: frequency, risk factors, and outcomes
F Saddadi1, M Hakemi, I Najafi
1Nephrology and Bone Marrow Transplant Research Center, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. saddadi_md@yahoo.com
Insights
Chronic kidney disease (CKD) occurred in 4% of hematopoietic cell transplantation (HCT) recipients. This study highlights the importance of monitoring for renal complications post-HCT, especially idiopathic CKD.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Chronic kidney disease (CKD) post-hematopoietic cell transplantation (HCT) is infrequently reported.
- This study aimed to determine the incidence of CKD in HCT recipients for various disorders.
Purpose of the Study:
- To prospectively evaluate the frequency of CKD after HCT.
- To identify risk factors associated with CKD development in HCT patients.
Main Methods:
- A prospective study involving 1963 HCT patients between 1997 and 2006.
- CKD defined as a doubling of serum creatinine from baseline and at 1 year post-transplant.
- Analysis of risk factors including conditioning regimen, graft type, graft-versus-host disease (GVHD), drug toxicity, and veno-occlusive disease (VOD).
Main Results:
- CKD developed in 66 patients (4%) post-HCT.
- Within 6-12 months, 33% of affected patients (23) were diagnosed with CKD, predominantly idiopathic.
- Other renal involvements included hypertension (17%), proteinuria (15%), and hematuria (18%).
Conclusions:
- The observed frequency of CKD in this HCT cohort appears high.
- Understanding the timing and type of renal injury is crucial for effective management.
- Further research is needed to optimize treatment strategies for CKD secondary to HCT.
Background:
Occurrence of chronic kidney disease (CKD) after hematopoietic cell transplantation (HCT) is rare with relatively few reported cases. The aim of this study was to evaluate the frequency of CKD among patients who received HCT for hematologic and nonhematologic disorders.
Objective:
We performed a prospective study to evaluate the frequency of CKD and its risk factors. Between 1997 and 2006 there were 1693 patients engrafted at the Bone Marrow Transplant Research Center.
Method:
CKD was defined as a doubling of serum creatinine level from the baseline and after 1 year from receiving a transplantation. The risk of CKD in relation to a non-based total body irradiation conditioning regimen, the type of graft (allograft autograft), and the incidences of graft-versus-host disease (GVHD), drug toxicity, and veno occlusive disease (VOD) were examined in 1963 HCT patients.
Results:
Kidney involvement developed in 66 patients (4%). By 6-12 months after HCT, approximately 33% of these patients developed CKD (23 patients: 19 allograft and 4 autograft). In most CKD patients, the cause was idiopathic. In 23 patients who developed CKD, 5 patients had acute kidney injury during the transplantation period with GVHD. Other renal involvements were as follows: hypertension (17%), proteinuria (15%), hydronephrosis (2%), hematuria (18%), and diabetes (3%).
Conclusion:
The frequency of CKD in this study seems to be high. It is important to know the specific type of kidney damage, to determine when to be aware of the time of occurrence of renal complications and to understand the best methods to treat patients with renal injury secondary to nephrotic syndrome and idiopathic CKD.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
01:16Kidney Transplant III: Nursing Management
01:28Kidney Transplant I: Introduction
01:25Chronic Kidney Disease I: Introduction
01:26Kidney Transplant II: Surgical Procedure
01:29Acute Kidney Injury III: Clinical Manifestations