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Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese

Toshiaki Nakano1, Toshiharu Ninomiya, Shinji Sumiyoshi

  • 1Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. toshink@med.kyushu-u.ac.jp

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|September 22, 2009
PubMed

Insights

Chronic kidney disease (CKD) is linked to more severe coronary atherosclerosis. Autopsy findings show advanced lesions and calcification increase as kidney function declines, highlighting CKD patients as high-risk for heart disease.

Area of Science:

  • Nephrology
  • Cardiology
  • Pathology

Background:

  • Chronic kidney disease (CKD) increases coronary heart disease risk.
  • Histopathologic data on coronary atherosclerosis in CKD patients is limited.
  • This study examines CKD's impact on coronary atherosclerosis severity.

Purpose of the Study:

  • To investigate the relationship between CKD and the severity of coronary atherosclerosis.
  • To analyze atherosclerotic lesion types, stenosis, and calcification in relation to kidney function.
  • To identify CKD as a risk factor for advanced coronary atherosclerosis.

Main Methods:

  • Cross-sectional study of 126 autopsy samples.
  • Estimated glomerular filtration rate (eGFR) calculated using the MDRD Study equation.
  • Generalized estimating equation methods used to evaluate CKD and atherosclerosis severity.

Main Results:

  • Advanced atherosclerotic lesions and coronary calcification increased with declining eGFR.
  • The association remained significant after adjusting for confounding factors.
  • Hypertension and diabetes exacerbated atherosclerosis in CKD patients.

Conclusions:

  • CKD is significantly associated with increased severity of coronary atherosclerosis.
  • CKD patients represent a high-risk population for advanced coronary atherosclerosis.
  • Limitations include the cross-sectional design and lack of proteinuria data.
Abstract

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