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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Updated: Jun 20, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Rethinking the pathogenesis of asthma.

Stephen T Holgate1, Donna E Davies

  • 1III Division, School of Medicine, University of Southampton, Southampton S016 61D, UK. s.holgate@soton.ac.uk

Immunity
|September 22, 2009
PubMed
Summary

Asthma research has overlooked non-allergic pathways. Focusing on airway resilience alongside immune modulation may yield better asthma treatments.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Genetics

Background:

  • Asthma research has predominantly focused on allergic (atopy) pathways, including Th2 T cells, cytokines, chemokines, and IgE.
  • Despite significant investment, targeting these allergic pathways has yielded limited new treatments beyond existing therapies like leukotriene and IgE blockade, inhaled corticosteroids, and bronchodilators.

Purpose of the Study:

  • To address the limitations of current asthma treatment strategies.
  • To explore alternative therapeutic targets beyond traditional allergic pathways.
  • To investigate the role of airway epithelial resilience in asthma pathogenesis.

Main Methods:

  • Review of existing asthma research focusing on allergic vs. non-allergic pathways.
  • Analysis of the heterogeneity of asthma.

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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Related Experiment Videos

Last Updated: Jun 20, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

  • Consideration of environmental and genetic factors influencing asthma.
  • Evaluation of airway epithelium structure and function in asthma.

    • Main Results:

    • Targeting solely allergic pathways has not led to significant breakthroughs in asthma treatment.
    • Asthma is a complex, heterogeneous disorder influenced by multiple factors beyond allergen sensitization.
    • Airway epithelium is often structurally and functionally deficient in individuals with asthma.

    Conclusions:

    • Current asthma treatments primarily address allergic inflammation, with limited success for many patients.
    • Future asthma research should consider the heterogeneity of the disease and explore non-allergic pathways.
    • Enhancing airway resilience to environmental insults, in addition to modulating adaptive immunity, may offer novel therapeutic strategies for asthma.