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Establishing the follicular helper identity

George Kassiotis1, Anne O'Garra

  • 1Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

Immunity
|September 22, 2009
PubMed
Summary

B-cell lymphoma 6 (Bcl-6) is a transcriptional repressor that is crucial for the development of follicular helper T (Tfh) cells. Yu et al. demonstrate that Bcl-6 directs Tfh cell differentiation, distinguishing them from other T helper subsets.

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