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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

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Published on: November 7, 2025

Late toxicity after postprostatectomy salvage radiation therapy.

Jennifer L Peterson¹, Steven J Buskirk, Michael G Heckman

¹Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology

|September 22, 2009

Summary

Salvage external beam radiotherapy (EBRT) after prostatectomy for rising PSA is curative. This study found that EBRT for detectable PSA after radical prostatectomy has a low risk of late complications.

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

Oncology
Radiation Oncology
Urologic Oncology

Background:

Radical prostatectomy (RP) is a primary treatment for prostate cancer.
A detectable prostate-specific antigen (PSA) level post-RP indicates potential residual disease.
Salvage external beam radiotherapy (EBRT) is an option for patients with rising PSA after RP.

Purpose of the Study:

To assess the incidence and severity of late toxicities following salvage EBRT in patients with detectable PSA post-RP.
To determine the safety profile of salvage EBRT in this specific clinical scenario.

Main Methods:

A cohort of 308 patients receiving salvage EBRT for detectable PSA post-RP was analyzed.
Treatment involved high-energy photons (6-20 MV) to a median dose of 64.8 Gy.
Patients were followed for late toxicity occurring >90 days post-EBRT.

Main Results:

Late toxicity was observed in 13% of patients (41/308).
Grade 2 urethral strictures occurred in 3.9% of patients.
An estimated 0.7% of patients experienced grade 3 or 4 complications by 5 years post-EBRT.

Conclusions:

Salvage EBRT is the sole curative treatment for detectable PSA post-RP.
This radiotherapy approach can be delivered with a low probability of significant late complications.