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Health-e-Child project: mechanical dyssynchrony in children with dilated cardiomyopathy

Fabien Labombarda1, Julie Blanc, Arnaud Pellissier

  • 1Hôpital Necker-Enfants Malades, Paris, France.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|September 22, 2009
PubMed

Insights

Pediatric dilated cardiomyopathy shows significant left ventricular mechanical dyssynchrony. Advanced imaging techniques detect this dyssynchrony, which correlates with impaired ventricular function and size in children.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Imaging
  • Biomedical Engineering

Background:

  • Left ventricular mechanical dyssynchrony is understudied in pediatric dilated cardiomyopathy.
  • Understanding dyssynchrony is crucial for assessing cardiac function in affected children.

Purpose of the Study:

  • To investigate the degree of left ventricular mechanical dyssynchrony in children with dilated cardiomyopathy.
  • To utilize tissue Doppler imaging and speckle tracking strain for dyssynchrony assessment.

Main Methods:

  • Compared 25 children with dilated cardiomyopathy to healthy controls.
  • Assessed radial and longitudinal dyssynchrony using speckle tracking strain and tissue Doppler imaging.
  • Measured left ventricular end-diastolic diameter to correlate with dyssynchrony, function, and remodeling.

Main Results:

  • Dyssynchrony parameters (radial and longitudinal) were significantly elevated in the dilated cardiomyopathy group.
  • Dyssynchrony correlated with left ventricular end-diastolic diameter Z-score.
  • A logarithmic correlation was observed between ejection fraction and ventricular diameter.

Conclusions:

  • Tissue Doppler imaging and speckle tracking strain effectively detect dyssynchrony in pediatric dilated cardiomyopathy.
  • Detected dyssynchrony is associated with the severity of left ventricular dysfunction.
Abstract

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