Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in platelet 5-hydroxytryptamine uptake in mania.

J B Meagher1, A O'Halloran, P A Carney

  • 1Department of Psychiatry, Riverview Hospital, Port Coquitlam, B.C., Canada.

Journal of Affective Disorders
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parent experiences of a remote patient monitoring program enabling early discharge from the neonatal intensive care unit with nasogastric tube feeding.

Journal of neonatal-perinatal medicine·2023
Same author

Point Prevalence of Frailty and Cognitive Impairment Exceeds the Capacity of a Single Ward - Specialist Geriatric Wards to lead Best Practice.

Irish medical journal·2023
Same author

Caring in the time of COVID-19, longitudinal trends in well-being and mental health in carers in Ireland: Evidence from the Irish Longitudinal Study on Ageing (TILDA).

Archives of gerontology and geriatrics·2022
Same author

How to detect high-performing individuals and groups: Decision similarity predicts accuracy.

Science advances·2020
Same author

Attitudinal change toward psychiatry during undergraduate medical training in Ireland.

Irish journal of psychological medicine·2018
Same author

SSRI differentiation: Pharmacology and pharmacokinetics.

Human psychopharmacology·2018

This study found significantly higher serotonin (5HT) platelet uptake in newly diagnosed manic patients compared to controls and schizophrenic patients. This elevated uptake normalized upon recovery, suggesting a potential biomarker for mania.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biochemistry

Background:

  • Serotonin (5HT) system dysregulation is implicated in various psychiatric disorders.
  • Platelet uptake of 5HT is a potential peripheral marker for central serotonergic activity.
  • Previous research on 5HT platelet uptake in mania has yielded inconsistent results.

Purpose of the Study:

  • To investigate [3H]5-Hydroxytryptamine (5HT) platelet uptake in drug-free manic patients.
  • To compare 5HT platelet uptake in manic patients with drug-treated manic and schizophrenic patients, and healthy controls.
  • To examine changes in 5HT platelet uptake during illness episode and recovery.

Main Methods:

  • Measurement of [3H]5-Hydroxytryptamine (5HT) uptake into platelets.
  • Comparison of uptake rates in hospitalized drug-free manic patients, drug-treated manic and schizophrenic patients, and control subjects.

Related Experiment Videos

  • Assessment of 5HT uptake at the beginning of the illness episode and at discharge for manic patients.

    • Main Results:

    • Significantly higher 5HT platelet uptake was observed in drug-free manic patients at the onset of illness compared to controls and schizophrenic patients.
    • No significant difference in 5HT uptake was found between schizophrenic patients and controls.
    • Manic patients exhibited normalized 5HT platelet uptake levels similar to controls upon discharge.
    • Manic patients without prior history of mania or depression showed markedly increased 5HT uptake compared to all other groups.

    Conclusions:

    • Elevated 5HT platelet uptake is a characteristic feature of the acute phase of mania, particularly in first-episode or treatment-naive patients.
    • This finding suggests a specific alteration in the serotonin transporter system during manic episodes.
    • 5HT platelet uptake may serve as a state-dependent biomarker for mania, normalizing with clinical improvement.