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Related Concept Videos

Robbers Cave04:49

Robbers Cave

During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension could be...
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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Updated: Jun 20, 2026

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling
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Armand M. Karow, Jr.: Looking back.

Gregory M Fahy1

  • 121st Century Medicine, Inc., 14960 Hilton Drive, Fontana, CA 92336, USA. gfahy@21cm.com

Cryobiology
|September 22, 2009
PubMed
Summary
This summary is machine-generated.

Armand Karow, Jr. pioneered cryobiology research, focusing on organ cryopreservation and exploring cryoprotectant effects. His work on freezing injury and low-temperature pharmacology offers future research directions.

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Area of Science:

  • Cryobiology and Organ Preservation
  • Low-Temperature Pharmacology
  • Cellular Physiology

Background:

  • Armand Karow, Jr. was a significant figure in cryobiology, driven by an early interest in organ cryopreservation.
  • His research spanned various organs including hearts, kidneys, and reproductive cells, as well as tissues.

Discussion:

  • Karow investigated conventional cryobiology topics like cryoprotectant permeation, freezing injury, and electromagnetic warming.
  • He also explored advanced areas such as high-pressure organ tolerance, molecular hydration's role in cell viability, and cryoprotectant pharmacology.

Key Insights:

  • Explored the pharmacological effects of cryoprotectants, referring to them as drugs.
  • Investigated the limits of cryoprotectant tolerance at elevated temperatures.
  • Examined the role of molecular hydration in maintaining cell viability during cryopreservation.

Outlook:

  • Karow's discoveries provide numerous avenues for future research in cryobiology.
  • Further investigation into his findings could yield significant advancements in organ and tissue preservation.