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Treatment of pediatric Gram-positive multidrug-resistant infections

Jeffrey Blumer1

  • 1Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5000, USA. Jeffrey.Blumer@UHhospitals.org

The Journal of Infection
|September 22, 2009
PubMed

Insights

Gram-positive bacterial infections are common in children. Pharmacokinetic and pharmacodynamic data help select appropriate antimicrobial treatments for pediatric patients, addressing resistance and developmental changes.

Area of Science:

  • Pediatric infectious diseases
  • Pharmacology
  • Microbiology

Background:

  • Gram-positive organisms cause the majority of bacterial infections in pediatric populations.
  • Antimicrobial therapy for children is often empirical due to evolving resistance patterns.
  • Pediatric patients undergo significant physiological changes affecting antibiotic disposition.

Purpose of the Study:

  • To highlight the importance of pharmacokinetic, pharmacodynamic, and pharmaceutical factors in pediatric antimicrobial selection.
  • To address the challenges in treating Gram-positive infections in infants, children, and adolescents.
  • To emphasize the availability of tools for appropriate antimicrobial agent selection.

Main Methods:

  • Review of pharmacokinetic, pharmacodynamic, and pharmaceutical determinants of antimicrobial efficacy.
  • Analysis of physiological changes in pediatric patients impacting antibiotic disposition.
  • Identification of tools for selecting appropriate antimicrobial agents.

Main Results:

  • Gram-positive infections constitute a significant burden in pediatric community-acquired and hospital-acquired settings.
  • Empirical antimicrobial treatment in children is common despite emerging resistance.
  • Pharmacological principles are crucial for effective antimicrobial therapy in pediatric patients.

Conclusions:

  • Effective antimicrobial treatment for Gram-positive infections in pediatric patients requires consideration of pharmacokinetic, pharmacodynamic, and pharmaceutical data.
  • Understanding developmental changes in antibiotic disposition is essential for optimizing therapy.
  • Utilizing specialized data enables appropriate antimicrobial selection for Gram-positive infections in children.

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