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Clinical Manifestations:

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Pleural Effusion I: Introduction

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Related Experiment Video

Updated: Jun 20, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Phlebolymphemeda: usually unrecognized, often poorly treated.

Nisha Bunke¹, Katherine Brown, John Bergan

¹Vein Institute of La Jolla, Department of Surgery, UCSD School of Medicine, La Jolla, California, USA.

Perspectives in Vascular Surgery and Endovascular Therapy

|September 22, 2009

Summary

Phlebolymphedema, a condition of venous and lymphatic insufficiency, is often overlooked and untreated. Early recognition through physical examination and treating the underlying venous issue can resolve lymphatic problems.

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

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Published on: May 1, 2015

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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

Vascular Medicine
Lymphology

Background:

Phlebolymphedema is a complex condition resulting from combined venous and lymphatic system dysfunction.
It is frequently underdiagnosed and undertreated, despite the interconnectedness of the vascular and lymphatic systems.
Venous hypertension, common in venous disorders, overwhelms lymphatic transport capacity, leading to fluid accumulation.

Purpose of the Study:

To highlight the nature of phlebolymphedema as a mixed venous and lymphatic insufficiency.
To emphasize the diagnostic criteria and treatment strategies for phlebolymphedema.

Main Methods:

Diagnosis relies on thorough patient history and physical examination.
Identification of characteristic skin changes associated with venous insufficiency is key.

Main Results:

Phlebolymphedema is often unrecognized and lacks specific treatment protocols.
Patients present with distinct skin manifestations of venous insufficiency.

Conclusions:

Effective management of phlebolymphedema involves addressing the primary venous abnormality.
Resolution of the lymphatic component is observed following successful treatment of the venous issue.