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Related Concept Videos

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.

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Related Experiment Video

Updated: Jun 20, 2026

Primary Culture of Dental Pulp Stem Cells
03:45

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Eph/ephrinB mediate dental pulp stem cell mobilization and function.

A Arthur1, S Koblar, S Shi

  • 1Bone and Cancer Laboratories, Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute/University of Adelaide, Frome Road, Adelaide 5000, SA, Australia.

Journal of Dental Research
|September 22, 2009
PubMed
Summary
This summary is machine-generated.

EphB/ephrin-B signaling in dental pulp stem cells (DPSC) influences their migration and differentiation after tooth injury. Forward signaling promotes proliferation, while reverse signaling enhances mineral production for dentin repair.

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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Area of Science:

  • Dentistry
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Dentin matrix damage triggers dental progenitor cell responses, but mechanisms remain unclear.
  • EphB receptors and ephrin-B ligands in the dental pulp perivascular niche are implicated in tooth injury.
  • Ephrin-B1 may inhibit dental pulp stem cell (DPSC) proliferation and migration post-injury.

Purpose of the Study:

  • To investigate the role of EphB/ephrin-B signaling in DPSC migration, proliferation, and differentiation following dentin matrix damage.
  • To elucidate the specific functions of EphB forward and reverse signaling in DPSC behavior.

Main Methods:

  • Utilized an established ex vivo tooth injury model to assess DPSC responses.
  • Performed in vitro assays to evaluate DPSC colony formation and differentiation.
  • Analyzed the effects of Eph/ephrin-B molecules on DPSC migration and proliferation.

Main Results:

  • EphB forward signaling was found to promote DPSC proliferation while inhibiting their migration.
  • EphB reverse signaling was observed to enhance mineral production in DPSCs.
  • Eph/ephrin-B interactions are crucial for directing DPSC migration and odontoblastic differentiation.

Conclusions:

  • EphB/ephrin-B signaling plays a critical role in the perivascular DPSC response to dentin injury.
  • These molecules guide DPSC migration towards dentin and their differentiation into odontoblasts for repair.
  • Understanding EphB/ephrin-B pathways offers potential for enhancing dentin regeneration strategies.