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Updated: Jun 20, 2026
09:01
Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
Published on: December 30, 2014
Where the immune response meets the vessel wall
R J Bisoendial1, E S G Stroes, P P Tak
1Department of Clinical Immunology and Rheumatology, University of Amsterdam, the Netherlands. r.j.bisoendial@amc.uva.nl
The Netherlands Journal of Medicine
|September 22, 2009
Summary
Immune-mediated inflammatory diseases (IMIDs) increase cardiovascular risks beyond traditional factors. Aggressively managing IMID inflammation may reduce heart disease and mortality, but specific guidelines are needed.
Area of Science:
- Rheumatology
- Cardiology
- Immunology
Background:
- Immune-mediated inflammatory diseases (IMIDs) are linked to higher cardiovascular morbidity and mortality.
- Chronic inflammation in IMIDs accelerates atherosclerosis, independent of traditional cardiovascular risk factors.
Purpose of the Study:
- To review the pathophysiology and observational evidence of cardiovascular risk in IMIDs.
- To highlight the need for specific cardiovascular risk reduction guidelines in IMID patients.
Main Methods:
- Literature review focusing on pathophysiology.
- Analysis of observational data on cardiovascular risk in IMIDs.
- Examination of cardiovascular risk in rheumatoid arthritis and spondyloarthritis prototypes.
Main Results:
- Chronic inflammation in IMIDs is a key driver of accelerated atherogenesis.
- Cardiovascular risks in IMIDs are significant and occur independently of established risk factors.
- Lack of randomized clinical trial data hinders specific guideline development.
Conclusions:
- Aggressive control of IMID disease activity is proposed for cardiovascular risk reduction.
- Further research, including randomized trials, is necessary to establish specific guidelines for cardiovascular risk management in IMID patients.
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