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Related Experiment Video

Updated: Jun 20, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Porous titanium for biomedical applications: an experimental study on rabbits.

Luana-Marotta-Reis de Vasconcellos1, Daniel-de Oliveira Leite, Fernanda-Oliveira Nascimento

  • 1Department of Bioscience and Buccal Diagnosis, São Jose dos Campos School of Dentistry, State University of São Paulo, São José dos Campos, Brazil. luanamrv@itelefonica.com.br

Medicina Oral, Patologia Oral Y Cirugia Bucal
|September 22, 2009
PubMed
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Porous titanium scaffolds, both fully porous and surface-porous with a dense core, effectively promote bone ingrowth. The surface-porous design demonstrated superior mechanical strength and integration for orthopedic applications.

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Tissue Engineering

Background:

  • Porous titanium scaffolds are crucial for bone regeneration.
  • Evaluating different porous titanium designs is essential for clinical success.
  • Powder metallurgy offers a viable method for scaffold fabrication.

Purpose of the Study:

  • To assess in vivo bone ingrowth in two distinct porous titanium scaffold types.
  • To compare the mechanical properties of fully porous versus surface-porous titanium scaffolds.
  • To determine the suitability of these scaffolds for orthopedic applications.

Main Methods:

  • Two groups of titanium scaffolds (fully porous and surface-porous/dense nucleus) were fabricated using powder metallurgy.
  • Scaffolds underwent metallographic analysis and compression testing.

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Related Experiment Videos

Last Updated: Jun 20, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

  • In vivo study involved implanting scaffolds in rabbits, followed by histological examination after 8 weeks.

    • Main Results:

    • Metallographic analysis showed interconnected pores (approx. 360 µm diameter, 36% porosity).
    • Compressive strength was significantly higher for surface-porous/dense nucleus scaffolds (69.27 MPa) compared to fully porous ones (16.19 MPa).
    • Histological examination confirmed bone ingrowth into the internal pores of both scaffold types within 8 weeks.

    Conclusions:

    • Both porous titanium scaffold designs facilitate bone ingrowth.
    • Titanium scaffolds with a porous surface and dense nucleus exhibit superior mechanical properties and tissue integration.
    • These findings support the use of surface-porous titanium scaffolds in orthopedic and regenerative medicine.