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Identification of a new prostate cancer susceptibility locus on chromosome 8q24
Meredith Yeager1, Nilanjan Chatterjee, Julia Ciampa
1Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA. yeagerm@mail.nih.gov
Nature Genetics
|September 22, 2009
Abstract:
We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
