[Results of a 10-year prospective study of patients with ischemic heart disease]

Area of Science:

• Cardiology
• Clinical Medicine
• Public Health

Background:

• Coronary heart disease (CHD) with stable angina pectoris affects numerous patients.
• Understanding long-term outcomes of CHD management is crucial for patient care.
• Previous studies have explored various therapeutic interventions for CHD.

Purpose of the Study:

• To analyze the 10-year outcomes of drug therapy in patients with coronary heart disease and stable angina pectoris.
• To evaluate the impact of long-term treatment on clinical status, work capacity, and lifespan.
• To investigate the relationship between coronary atherosclerosis progression and clinical deterioration.

Main Methods:

• A 10-year prospective study involving 396 patients with CHD and stable angina.
• Coronary angiography and ventriculography were used to assess coronary artery stenosis and left ventricular function.
• Long-term drug therapy was administered, and patient outcomes were monitored.

Main Results:

• Long-term drug therapy led to improved clinical status, maintained work capacity, and increased lifespan in most patients.
• The annual mortality rate was 3.0%, and the incidence of nonfatal myocardial infarction was 5.9%.
• Repeated coronary angiography revealed that progression of coronary atherosclerosis was associated with clinical deterioration and decreased exercise tolerance.

Conclusions:

• Long-term drug therapy offers significant clinical benefits for patients with coronary heart disease and stable angina.
• Monitoring coronary atherosclerosis progression is essential for predicting clinical outcomes and managing patient health.
• Further research should focus on optimizing therapeutic strategies to mitigate atherosclerosis progression and improve long-term prognosis in CHD patients.