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Effect of prostaglandin E in multiple experimental models: V. Effect on tumor/host interaction
1Shriners Burns Institute, Cincinnati, Ohio.
Journal of Surgical Oncology
|October 1, 1990
Summary
Prostaglandin E (PGE) affects tumor growth and host metabolism. While a PGE derivative slowed tumor growth, it also reduced body mass and altered amino acid levels in cancer patients.
Area of Science:
- Biochemistry
- Immunology
- Oncology
Background:
- Prostaglandin E (PGE) is linked to immunosuppression in cancer patients.
- PGE is suspected to impair immune response, promoting tumor growth.
Purpose of the Study:
- To investigate the impact of Prostaglandin E on tumor-host interactions.
- To analyze the metabolic effects of a long-acting PGE derivative in vivo.
Main Methods:
- Utilized a parenterally administered long-acting PGE derivative: 16,16-dimethyl-prostaglandin E (dPGE).
- Assessed tumor growth rates, tumor-free body mass, resting metabolic rates, brain dopamine metabolism, and serum amino acid levels.
Main Results:
- dPGE administration decreased tumor growth rate.
- dPGE administration decreased tumor-free body mass.
- dPGE altered brain dopamine metabolism and significantly decreased serum amino acid levels, without affecting resting metabolic rates.
Conclusions:
- Elevated Prostaglandin E levels can significantly alter host metabolism in tumor-bearing patients.
- The findings suggest a complex role of PGE in cancer, impacting both tumor progression and host physiology.