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Spontaneous pyopneumothorax in patients treated with mTOR inhibitors for subpleural pulmonary metastases
Sylvain Ladoire1, Caroline Beynat, Pierre Diaz
1Department of Medical Oncology, Centre Georges François Leclerc, 1 rue du Professeur Marion, 21000, Dijon, France. sladoire@dijon.fnclcc.fr
Abstract:
Spontaneous pyopneumothorax is a very rare occurrence, even in cancer treated patients. Here we present two consecutive cases of spontaneous pyopneumothorax that occurred early after initiation of mTOR inhibitors for the treatment of renal cell carcinoma with subpleural pulmonary metastasis. In these two cases, necrosis and excavation of lung metastasis were observed, suggesting their involvement in the pathogenic mechanism of pyopneumothorax. This report extends the available experience of the pulmonary side effects of these novel targeted therapies.
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Pneumothorax-II
Clinical Manifestations:
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Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
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The first classification is based on the development of the disease, and it includes the following categories: