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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
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Management of Insomnia01:19

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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Related Experiment Video

Updated: Jun 20, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

[Circadian rhythm sleep disorders].

Hirokuni Tagaya1

  • 1Department of Health Sciences, School of Allied Health Sciences, Kitasato University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 23, 2009
PubMed
Summary

The body's internal clock regulates sleep-wake cycles. Circadian rhythm sleep disorders (CRSDs) arise from mismatches between this clock and daily schedules, with bright light therapy and melatonin offering effective treatments.

Area of Science:

  • Chronobiology
  • Sleep Medicine
  • Neuroscience

Context:

  • The circadian system acts as the body's master clock, governing the ~24-hour sleep-wake cycle.
  • Environmental cues, primarily sunlight, entrain the internal clock to the external day-night cycle.
  • Circadian rhythm sleep disorders (CRSDs) occur when the internal clock is misaligned with social schedules.

Purpose:

  • To define circadian rhythm sleep disorders (CRSDs) and their common symptoms.
  • To differentiate between acute CRSDs (jet lag, shift work) and those with unclear pathophysiology.
  • To outline effective treatment strategies for CRSDs, focusing on circadian entrainment.

Summary:

  • CRSDs manifest as insomnia, hypersomnia, headaches, or gastrointestinal issues, potentially impairing social functioning.

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Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
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Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

  • Jet lag and shift work disorders result from abrupt schedule shifts exceeding the circadian system's entrainment capacity.
  • Bright light therapy (BLT) and melatonin administration are key treatments, while hypnotics are generally ineffective for CRSDs.
  • Impact:

    • Highlights the impact of CRSDs on daily functioning and social life.
    • Clarifies the role of circadian entrainment in managing sleep disorders.
    • Emphasizes evidence-based treatments, guiding clinical practice and patient management for CRSDs.