Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Insomnia

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...

Management of Insomnia

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuroinflammation, Oxidative Stress, and Neurogenesis in a Mouse Model of Chronic Fatigue Syndrome, and the Treatment with Kampo Medicine.

Biological & pharmaceutical bulletin·2020

Same author

Clonazepam improves dopamine supersensitivity in a schizophrenia patient: a case report.

Therapeutic advances in psychopharmacology·2017

Same author

The Contribution of Increased Gamma Band Connectivity to Visual Non-Verbal Reasoning in Autistic Children: A MEG Study.

PloS one·2016

Same author

Does sleep improve memory organization?

Frontiers in behavioral neuroscience·2014

Same author

Regional analysis of differently phosphorylated tau proteins in brains from patients with Alzheimer's disease.

Dementia and geriatric cognitive disorders·2004

Same author

[Nocturnal eating (drinking) syndrome].

Ryoikibetsu shokogun shirizu·2003

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

[Insomnia in old age].

Reizo Kaneda¹, Hisakazu Furuta

¹Department of Psychiatry and Neurobiology, Kanazawa University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|September 23, 2009

Summary

This summary is machine-generated.

Sleep problems like insomnia are common in older adults due to changes in the body

More Related Videos

Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Related Experiment Videos

Last Updated: Jun 20, 2026

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Area of Science:

Gerontology
Sleep Medicine
Neuroscience

Context:

Aging is associated with significant alterations in sleep architecture and circadian rhythms.
The prevalence of insomnia and hypnotic medication use escalates with age.
Physical and psychiatric comorbidities, restless legs syndrome, and sleep-disordered breathing are prevalent in the elderly population, impacting sleep quality.

Purpose:

To explore the multifaceted causes of sleep disturbances in the aging population.
To highlight the increasing incidence of insomnia and medication use in the elderly.
To underscore the role of various health conditions in age-related sleep decline.

Summary:

Sleep structure changes with aging due to circadian system shifts and reduced physical activity.
Insomnia prevalence and sleeping pill consumption rise in older adults.
Co-existing physical and psychiatric conditions, restless legs syndrome, and sleep-disordered breathing exacerbate poor sleep in the elderly.

Impact:

Early and effective interventions for insomnia can significantly enhance health and quality of life for elderly individuals.
Understanding these age-related sleep changes is crucial for developing targeted therapeutic strategies.
Addressing sleep issues in the elderly can lead to broader improvements in overall well-being and healthcare outcomes.