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Mifepristone followed by high-dose oxytocin drip for second-trimester abortion: a randomized, double-blind,
Assaf Ben-Meir1, Yair Erez, Tomer Feigenberg
1Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, Jerusalem 91120m Israel. assaf.benmeir@gmail.com
Objective:
To study the effect of mifepristone for priming and induction of second-trimester abortion in conjunction with a high-concentration oxytocin drip.
Study Design:
Prospective, randomized, placebo-controlled, pilot study. Thirty patients with 14-25 weeks' gestational age abortion received either 600 mg of mifepristone or placebo in 3 identical capsules followed, 48 hours later, by a high-concentration oxytocin drip (HCOD).
Results:
The mifepristone group showed significantly higher success rates as compared to the placebo group (92.3% vs. 52.9%, p<0.05). The time interval to abortion (from beginning of HCOD) was also significantly shorter in the mifepristone group as compared to the placebo group (11.3 +/- 6.0 hours vs. 17.6 +/- 6.5 hours, p <0.05). Probability of success as calculated by the Kaplan-Meier method was found to be highly significant (log rank test p = 0.001).
Conclusion:
Our results suggest that mifepristone is very effective for priming and induction of second-trimester abortion and shortens significantly the time interval to evacuation following HCOD.
