Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of intra-oceanic trench bending and along-trench thermochemical transport by mantle toroidal flow.

Nature communications·2026
Same author

Mitochondrial dysfunction and programmed cell death in Alzheimer's disease: A retrospective bioinformatics study.

Medicine·2026
Same author

[Shenzao Jiannao Oral Liquid treats Alzheimer's disease by regulating gut microbiota].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same author

A Whole-Cell Catalytic System for Equol Production Based on Daidzein Reductase Engineering.

Molecules (Basel, Switzerland)·2026
Same author

[Characteristics， Ecological Risk Assessment， and Source Apportionment of Soil Heavy Metals in the Zhangbei County of the Plateau of Inner Mongolia].

Huan jing ke xue= Huanjing kexue·2026
Same author

Constructing Denser Hydrogen-Bonding Networks in Polyoxometalate-Based Coordination Polymers for Enhancing Proton Conduction.

Inorganic chemistry·2026
Same journal

[Case of concurrent second branchial cleft cyst and diffuse large B-cell lymphoma].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2026
Same journal

[Double-layer ceramic technique for restoring severely discolored nonvital maxillary anterior teeth: a case report].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2026
Same journal

[Effectiveness and cost-effectiveness of risk-based topical fluoride intervention on early childhood caries in Jiangnan District, Nanning City].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2026
Same journal

[Expression of Rho-related BTB domain-containing protein 1 in tongue squamous cell carcinoma and its effect on cell proliferation, invasion, and migration].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2026
Same journal

[Effect of pioglitazone on periodontitis-related renal injury in mice and its relationship with Klotho].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2026
Same journal

[Chinese introduction to the Preferred Reporting Items for Randomized Trials in Endodontics 2020 checklist].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

[Heterotopic complex membrane induces bone formation].

Chong-tao Lin1, Hong-yan Li, Jia-qing Yan

  • 1Dept. of Periodontology, Stomatology Hospital of Jilin University, Changchun 130041, China.

Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology
|September 23, 2009
PubMed
Summary
This summary is machine-generated.

The study shows that a composite membrane containing recombinant human bone morphogenetic protein-2 (rhBMP-2) with collagen (Co) and polylactic-co-glycolic acid (PLGA) effectively promotes ectopic bone formation. This rhBMP-2/Co/PLGA membrane demonstrated enhanced biological activity compared to a membrane without rhBMP-2.

More Related Videos

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

Related Experiment Videos

Last Updated: Jun 20, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Developing effective carriers for bone morphogenetic proteins is crucial for bone regeneration.
  • Composite membranes offer potential for controlled delivery of therapeutic agents.
  • Polylactic-co-glycolic acid (PLGA) and collagen (Co) are biocompatible materials often used in tissue engineering scaffolds.

Purpose of the Study:

  • To evaluate the capability of a composite membrane made of recombinant human bone morphogenetic protein-2 (rhBMP-2), collagen (Co), and polylactic-co-glycolic acid (PLGA) for ectopic bone formation.
  • To compare the biological activity and degradation profile of the rhBMP-2/Co/PLGA membrane versus a Co/PLGA membrane without rhBMP-2.

Main Methods:

  • Forty-eight male Kunming mice were randomly assigned to two groups: Co/PLGA complex membrane and rhBMP-2/Co/PLGA complex membrane.
  • Complex membranes were implanted into the hind limb muscle pouch of mice.
  • Samples were analyzed at 7, 14, and 28 days using soft X-ray, HE staining, and light microscopy.

Main Results:

  • No infections or rejections were observed in either group.
  • The Co/PLGA membrane showed degradation and absorption by 28 days with no ectopic bone formation.
  • The rhBMP-2/Co/PLGA membrane exhibited significant ectopic bone formation and slower degradation, indicating enhanced biological activity.

Conclusions:

  • The Co/PLGA composite membrane serves as an effective carrier for rhBMP-2, enhancing its biological activity.
  • The rhBMP-2/Co/PLGA membrane demonstrates potential for promoting bone regeneration through ectopic bone formation.