Chinese medicinal herbs in relieving perimenopausal depression: a randomized, controlled trial

Area of Science:

• Integrative Medicine
• Pharmacology
• Women's Health

Background:

• Perimenopausal depression is a significant concern for many women.
• Chinese medicinal herbs offer potential therapeutic avenues for menopausal symptoms.

Purpose of the Study:

• To evaluate the efficacy of GengNianLe (GNL), a Chinese herbal formula, in alleviating perimenopausal depression.
• To compare the effects of GNL with tibolone on depression and hormonal profiles in perimenopausal women.

Main Methods:

• A randomized controlled trial involving 47 Chinese women with perimenopausal depression.
• Participants were assigned to either the GNL group or a control group receiving tibolone.
• Depression was assessed using the Hamilton Depression Scale (HAMD), and serum hormone levels (FSH, LH, E2) were measured before and after treatment.

Main Results:

• After 12 weeks, both GNL and tibolone significantly reduced HAMD scores (p < 0.05) with no significant inter-group difference.
• Significant decreases in FSH and increases in E2 were observed in both groups, with more pronounced changes in the tibolone group.
• No adverse side effects were reported for either treatment during the study period.

Conclusions:

• The Chinese medicinal formula GNL demonstrates potential for relieving perimenopausal depression.
• GNL warrants further investigation as a treatment option for perimenopausal depression.