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Updated: Jun 20, 2026
03:55
A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
Novel insights into hydrogen sulfide--mediated cytoprotection
John W Calvert1, William A Coetzee, David J Lefer
1Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Antioxidants & Redox Signaling
|September 23, 2009
Summary
Hydrogen sulfide (H(2)S) protects cells from injury, particularly in the heart and liver. This review details its cytoprotective effects and the signaling pathways involved.
Area of Science:
- Biochemistry
- Physiology
- Toxicology
Background:
- Hydrogen sulfide (H(2)S) was historically viewed as a toxic gas.
- Recent discoveries reveal endogenous H(2)S production in mammals.
- H(2)S is now recognized as a signaling molecule with physiological roles.
Purpose of the Study:
- To review the cytoprotective effects of H(2)S.
- To emphasize the cardioprotective actions of H(2)S.
- To describe the signaling mechanisms underlying H(2)S cardioprotection.
Main Methods:
- Literature review of studies on H(2)S and cellular injury.
- Analysis of research on H(2)S administration in ischemia-reperfusion models.
- Examination of endogenous H(2)S roles in physiological conditions.
Main Results:
- H(2)S demonstrates cytoprotective effects in various cellular injury models.
- Acute H(2)S administration ameliorates myocardial and hepatic ischemia-reperfusion injury.
- Endogenous H(2)S plays a significant cardioprotective role.
Conclusions:
- H(2)S exhibits significant cytoprotective and cardioprotective properties.
- Understanding H(2)S signaling mechanisms is crucial for therapeutic applications.
- Further research into H(2)S is warranted for its potential health benefits.
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