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Related Experiment Video

Updated: Jun 20, 2026

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Engineering a titanium and polycaprolactone construct for a biocompatible interface between the body and artificial

Cynthia M Smith1, Tithi Dutta Roy, Abhijeet Bhalkikar

  • 1nScrypt, Inc Orlando, Florida 32826, USA. cindy.m.smith@gmail.com

Tissue Engineering. Part A
|September 23, 2009
PubMed
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This study developed a novel titanium and polycaprolactone (PCL) construct for intraosseous transcutaneous amputation prostheses. The engineered design enhances skin adhesion, potentially improving prosthetic viability for amputees.

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Prosthetics Development

Background:

  • Conventional stump-socket prostheses face challenges due to nonuniform pressure distribution.
  • Transcutaneous amputation devices have shown limited success in clinical applications.
  • Optimizing the skin-prosthetic attachment is crucial for improving intraosseous transcutaneous amputation prostheses viability.

Purpose of the Study:

  • To develop and evaluate a novel engineered titanium and polycaprolactone (PCL) construct for intraosseous transcutaneous amputation prostheses.
  • To enhance the adherence between the titanium implant and the skin interface.
  • To assess the biocompatibility and antibacterial properties of the developed construct.

Main Methods:

  • Fabrication of a modified titanium construct with a specialized surface for increased tissue adherence.

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Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
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Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

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Last Updated: Jun 20, 2026

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

  • Computer-aided design and fabrication of polycaprolactone (PCL) scaffolds with controlled architecture and porosity (>50%).
  • Assessment of PCL scaffold tensile strength, cell viability after neutralization, and antibacterial properties of various antimicrobial agents in collagen or hyaluronic acid (HA).

    • Main Results:

    • A specially machined titanium surface significantly increased PCL scaffold adhesion.
    • Neutralized PCL scaffolds exhibited only a 10% decrease in cell viability.
    • The addition of 1% chlorhexidine diacetate in HA reduced bacterial presence by 71% compared to untreated HA.

    Conclusions:

    • The developed engineered titanium and PCL construct shows promise for improving the titanium-skin interface in intraosseous transcutaneous amputation prostheses.
    • The enhanced adhesion and potential for controlled antibacterial properties suggest clinical viability.
    • Further research into this novel biomaterial construct could lead to improved prosthetic solutions for amputees.