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Prevalence of obstructive sleep disturbance in children with failure to thrive
Rebecca S Stone1, Jeffrey H Spiegel
1Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts, USA.
Insights
Occult obstructive sleep disturbance (OSD) was studied in children with failure to thrive (FTT). While OSD prevalence was higher in FTT patients, it did not reach statistical significance compared to the general pediatric population.
Area of Science:
- Pediatric Medicine
- Sleep Medicine
- Child Development
Background:
- Failure to thrive (FTT) is a critical condition in children characterized by inadequate growth.
- Occult obstructive sleep disturbance (OSD) is a potential, yet under-investigated, cause of FTT.
- Understanding the prevalence of OSD in FTT is crucial for diagnosis and treatment.
Purpose of the Study:
- To determine the prevalence of OSD in children diagnosed with FTT.
- To explore the correlation between OSD, tonsil size, and parental-reported symptoms.
- To compare OSD prevalence in FTT patients with general pediatric norms.
Main Methods:
- A cross-sectional study involving 36 FTT children (12-60 months) at Boston Medical Center.
- Evaluations included formal polysomnography, parental questionnaires, and physical examinations.
- Results were compared against established age-appropriate norms for sleep disorders.
Main Results:
- The prevalence of OSD in the studied FTT population was 5.5%.
- This prevalence is higher than the general pediatric population (0.7%–4.3%) but did not achieve statistical significance.
- No significant correlation was found to establish OSD as a primary cause for FTT in this cohort.
Conclusions:
- The study did not find a statistically significant increase in OSD prevalence among children with FTT.
- Despite non-significant findings, maintaining clinical suspicion for OSD in FTT cases is essential.
- The observed growth improvements after sleep disturbance management (e.g., tonsillectomy) in FTT children are not fully explained by a higher incidence of OSD.
Objectives:
Failure to thrive (FTT) is a serious condition of childhood, with failure to grow as expected for age and gender. Numerous potential etiologies have been suggested, including occult obstructive sleep disturbance (OSD). We determined the prevalence of OSD in an FTT population, examined correlation to tonsil size, and assessed correlation with a parental questionnaire regarding symptoms.
Patients And Methods:
A cross-sectional prevalence study was conducted. Thirty-six FTT children in Boston Medical Center's FTT Clinic aged 12 to 60 months were evaluated by formal polysomnography, parental questionnaire, and physical examination. The prevalence and nature of sleep disorders in this population are compared with published age-appropriate norms.
Results:
The prevalence of OSD in an FTT population in these 36 children is 5.5%. This is compared with the prevalence in the general pediatric population, which is between 0.7 and 4.3%.
Conclusions:
The prevalence of OSD in FTT tends toward higher than published values for the general pediatric population but does not reach statistical significance. Tonsillectomy and adenoidectomy have been suggested in the literature to be of benefit to improve the growth of children with FTT. Sleep disturbance has been suggested as the underlying pathology. However, using current guidelines, we could not identify an increased prevalence of sleep disturbance in children with FTT. Nonetheless, a continued high level of clinical suspicion is necessary in appropriate diagnosis and treatment of OSD, found in some children with FTT. That growth in children with FTT often improves following management of sleep disturbance (eg, tonsillectomy) is not explained by a significantly higher incidence of OSD in this population.
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