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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Parameter-optimized model of cardiovascular-rotary blood pump interactions
Einly Lim1, Socrates Dokos, Shaun L Cloherty
1Graduate School of Biomedical Engineering, University of New South Wales, Sydney, N.S.W. 2052, Australia. z3179719@student.unsw.edu.au
IEEE Transactions on Bio-Medical Engineering
|September 23, 2009
Summary
A new cardiovascular model simulates rotary blood pump interactions, aiding heart failure research and control algorithm development. This tool enhances understanding of circulatory responses to blood pump assistance.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
- Medical Device Simulation
Background:
- Cardiovascular implantable rotary blood pumps (iRBPs) are crucial for treating heart failure.
- Accurate modeling of iRBP-cardiovascular interactions is essential for device development and clinical application.
Purpose of the Study:
- To develop and validate a lumped parameter model of human cardiovascular-iRBP interaction.
- To investigate the influence of various physiological and device-specific factors on circulatory response.
- To provide a platform for evaluating rotary blood pump assistance under simulated heart failure conditions.
Main Methods:
- Development of a lumped parameter model incorporating left/right heart, circulations, and iRBP.
- Optimization of model parameters using experimental data from healthy pigs (pressures, flows, pump variables).
- Simulation of circulatory response to iRBP assistance under altered model parameters mimicking heart failure.
Main Results:
- The fitted model accurately reproduced experimental measurements across various pump operating points.
- Identified key factors influencing circulatory response, including end-systolic pressure-volume relationship, suction resistance, and respiration.
- Demonstrated the model's capability to simulate iRBP effects under simulated heart failure.
Conclusions:
- The developed lumped parameter model is a valuable tool for understanding cardiovascular-iRBP interactions.
- The model aids in designing experiments and developing robust physiological control algorithms for rotary blood pumps.
- This simulation platform supports the advancement of iRBP technology for heart failure management.
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