Comparison of MRI-based thrombolysis for patients with middle cerebral artery occlusion<or=3 h and 3-6 h
Related Experiment Video
Updated: Jun 20, 2026
Transient Middle Cerebral Artery Occlusion Model of Stroke
Published on: August 11, 2023
Yue-Hua Li1, Ming-Hua Li, Zhen-Guo Zhao
1Department of Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, Shanghai, China. leeyuehuaxp@gmail.com
Objective:
To investigate the outcomes of magnetic resonance imaging (MRI)-based thrombolysis using recombinant tissue plasminogen activator (rt-PA) in patients with acute middle cerebral artery (MCA) occlusion in 3-6 hours.
Materials And Methods:
MRI-selected patients (n=15) with acute ischemic stroke in MCA divided into two groups (
Results:
There was no significant between
Conclusion:
Our study suggested that MR-based thrombolysis using rt-PA was safe and reliable in patients with acute MCA occlusion in 3-6 hours.
Insights
Magnetic resonance imaging (MRI)-guided thrombolysis with recombinant tissue plasminogen activator (rt-PA) is safe for acute middle cerebral artery (MCA) occlusion. This treatment shows promising outcomes, including recanalization and improved clinical status, regardless of treatment timing.
Area of Science:
- Neurology
- Radiology
- Cardiovascular Medicine
Background:
- Acute ischemic stroke due to middle cerebral artery (MCA) occlusion requires timely intervention.
- Recombinant tissue plasminogen activator (rt-PA) is a standard thrombolytic agent.
- Magnetic resonance imaging (MRI) can aid in patient selection and treatment monitoring.
Purpose of the Study:
- To evaluate the safety and efficacy of MRI-guided rt-PA thrombolysis for acute MCA occlusion within 3-6 hours.
- To compare outcomes between early (
Main Methods:
- Fifteen patients with acute ischemic stroke in the MCA were selected using MRI and treated with intravenous rt-PA.
- Patients were divided into two groups:
- Clinical status was assessed using the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS); recanalization and intracranial hemorrhage (ICH) were monitored via MRI.
Main Results:
- Recanalization occurred in 60% of patients within 24 hours.
- No significant differences were observed in hospital stay, recanalization rates, MRS, or favorable outcomes at 90 days between the two treatment time groups.
- Recanalization was associated with better outcomes, including lower NIHSS scores at 14 days and shorter hospital stays, irrespective of treatment timing.
Conclusions:
- MRI-based thrombolysis with rt-PA is a safe and reliable treatment option for acute MCA occlusion within 3-6 hours.
- The study supports the use of rt-PA in this patient population, highlighting the benefits of recanalization.
