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Gene expression profiling: classification of mice with left ventricle systolic dysfunction using microarray analysis.

Jim Wong1, Christine Chang, Rani Agrawal

  • 1Department of Anesthesia, Stanford University, Stanford, CA, USA.

Critical Care Medicine
|September 23, 2009
PubMed
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A set of 83 differentially expressed genes accurately classifies mice by cardiovascular phenotype after catecholamine stress, distinguishing between systolic and diastolic dysfunction. This finding aids in understanding stress-induced cardiac responses.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Genomics

Background:

  • Prolonged catecholamine stress can induce distinct cardiovascular phenotypes.
  • Understanding the genetic basis of these phenotypes is crucial for developing diagnostic tools.

Purpose of the Study:

  • To test if a gene expression signature can classify mice based on cardiovascular phenotype after catecholamine stress.
  • To identify genes associated with systolic dysfunction.

Main Methods:

  • A prospective, randomized study involving 173 male mice of various genotypes (wild-type and beta2 adrenergic receptor knockout).
  • Mice received 14-day infusions of isoproterenol or no treatment.
  • Gene expression profiling (microarray) and left ventricle pressure-volume loop analysis were performed.

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Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
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Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

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Related Experiment Videos

Last Updated: Jun 20, 2026

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
10:22

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

Published on: October 26, 2017

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
08:23

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

Main Results:

  • Wild-type FVB and knockout mice developed systolic dysfunction; wild-type C57 mice developed diastolic dysfunction.
  • A set of 83 differentially expressed genes was identified, correlating with left ventricle systolic dysfunction.
  • This 83-gene set accurately classified mice with systolic dysfunction in a separate cohort.

Conclusions:

  • The expression pattern of 83 genes serves as an accurate classifier for physiological phenotypes following catecholamine stress.
  • This gene set holds potential for diagnosing stress-induced cardiovascular conditions.