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Updated: Jun 20, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Tissue array methods for high-throughput clinicopathologic research.

Hye Seung Lee1, Woo Ho Kim

  • 1Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.

Cancer Research and Treatment
|September 23, 2009
PubMed
Summary
This summary is machine-generated.

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High-throughput tissue arrays enable rapid validation of novel molecular markers for diagnostics and therapeutics. This method accelerates clinicopathologic research by analyzing numerous tissue specimens simultaneously.

Area of Science:

  • Molecular biology
  • Pathology
  • Biotechnology

Background:

  • Novel molecular markers are crucial for advancing diagnostics, prognostics, and therapeutics.
  • Efficient methods are needed to validate these markers in large-scale studies.

Purpose of the Study:

  • To provide an overview of the high-throughput tissue array method.
  • To highlight its application in clinicopathologic research for marker validation.

Main Methods:

  • Utilizes high-throughput tissue array technology for simultaneous analysis of numerous tissue specimens.
  • Employs techniques like immunohistochemistry and in situ hybridization for slide analysis.

Main Results:

  • Tissue arrays facilitate the validation of a significant number of novel molecular markers.
Keywords:
ImmunohistochemistryIn situ hybridizationTissue arrayTranslational research

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Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer
12:03

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer

Published on: June 10, 2022

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Last Updated: Jun 20, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer
12:03

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer

Published on: June 10, 2022

  • Enables high-throughput clinicopathologic research.

    • Conclusions:

    • The high-throughput tissue array method is a powerful tool for accelerating the discovery and validation of clinically significant molecular markers.
    • Its application significantly advances clinicopathologic research and biomarker development.