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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
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The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
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Antipsychotic Drugs: Typical and Atypical Agents01:21

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Antidepressant Drugs: MAOIs and Other Agents

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Related Experiment Video

Updated: Jun 20, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
08:38

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Published on: September 1, 2011

Hyperprolactinaemia with amisulpride.

Rajnish Raj1, Balwant Singh Sidhu

  • 1Department of Psychiatry, GMC and Rajindra Hospital, Patiala, India.

Indian Journal of Psychiatry
|September 23, 2009
PubMed
Summary
This summary is machine-generated.

Amisulpride, an antipsychotic, affects dopamine transmission differently based on dosage. Low doses can cause hyperprolactinemia, leading to side effects like galactorrhea, which improve with treatment adjustments.

Keywords:
ARIZONA Sexual Experience Scale (ASEX)Amisulpridegalactorrhoeahyperprolactinaemia

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Last Updated: Jun 20, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
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Published on: October 4, 2021

Area of Science:

  • Pharmacology
  • Neuroscience
  • Endocrinology

Background:

  • Amisulpride is a second-generation antipsychotic drug.
  • It selectively targets dopamine D2/D3 receptors.
  • Its action varies between limbic and striatal pathways.

Purpose of the Study:

  • To elucidate the differential effects of amisulpride on dopamine transmission.
  • To understand the mechanism of amisulpride-induced hyperprolactinemia.
  • To outline management strategies for associated side effects.

Main Methods:

  • Review of pharmacological data on amisulpride.
  • Analysis of receptor binding profiles.
  • Clinical observation of dose-dependent effects.

Main Results:

  • High-dose amisulpride antagonizes postsynaptic receptors, reducing dopamine transmission.
  • Low-dose amisulpride blocks presynaptic receptors, enhancing dopamine transmission.
  • Low-dose (50 mg/day) is associated with hyperprolactinemia, causing galactorrhea, amenorrhea, and sexual dysfunction.

Conclusions:

  • Amisulpride's therapeutic effects are dose-dependent.
  • Hyperprolactinemia is a significant side effect of low-dose amisulpride.
  • Management involves drug withdrawal, switching medications, or dopamine agonist therapy.