Related Experiment Video

Updated: Jun 20, 2026

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis
14:58

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

Linkage between immunomodulation, neuroprotection and neurogenesis

Rina Aharoni1, Ruth Arnon

  • 1Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

Drug News & Perspectives
|September 23, 2009
PubMed

Neuronal protection and restoration are the major goals for the therapy of neurodegenerative diseases, representing a very active field of research. In multiple sclerosis, treatments need to target both the autoimmune inflammation and the pathological neurodegeneration. The optimal therapeutic approach may promote remyelination and axonal repair, and even lead to neuronal renewal. This review article will discuss both endogenous neuroprotective mechanisms and those triggered by potential therapies. Currently employed immunomodulatory treatments and their ability to induce neuroprotection, tissue repair and neurogenesis are also presented.

More Related Videos

Neuron-Macrophage Co-cultures to Activate Macrophages Secreting Molecular Factors with Neurite Outgrowth Activity08:52

Neuron-Macrophage Co-cultures to Activate Macrophages Secreting Molecular Factors with Neurite Outgrowth Activity

Published on: March 30, 2018

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...