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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
Published on: July 25, 2022
[Vaccine safety].
K Weisser1, I Barth, B Keller-Stanislawski
1Bundesinstitut für Sera und Impfstoffe (PEI), Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen. weika@pei.de
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
|September 23, 2009
Summary
Vaccine safety is rigorously tested, but very rare side effects can emerge post-market. Public concern over these risks, often exaggerated, can lower vaccination rates, increasing disease outbreaks.
Area of Science:
- Immunology
- Public Health
- Pharmacovigilance
Context:
- Vaccines are crucial for preventing infectious diseases, with high safety standards.
- Public perception of vaccine risks has grown, partly due to the success of vaccination programs.
- This has led to increased awareness of both real and perceived adverse events following immunization (AEFI).
Purpose:
- To review the scientific evidence on the causality and frequency of specific AEFI.
- To address concerns regarding vaccine risks versus benefits.
- To provide a balanced perspective on vaccine safety and potential adverse events.
Summary:
- Vaccine safety is ensured through extensive pre-clinical and clinical testing, identifying common and rare adverse events.
- Very rare adverse events may only become apparent after widespread vaccine use.
- Declining vaccination rates due to fear of rare events can lead to resurgence of preventable diseases.
Impact:
- Accurate assessment of AEFI is vital for maintaining public trust in vaccination.
- Understanding the true frequency and causality of AEFI helps in risk-benefit communication.
- This review aims to counter misinformation and support informed decision-making regarding immunizations.
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