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Related Concept Videos

Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

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Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis.

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Baseline characteristics of atopic eczema patients enrolled in seven European registries united in the TREatment of ATopic eczema (TREAT) registry taskforce.

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Related Experiment Video

Updated: Jun 20, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

[Inside-Out. Probiotics and atopic dermatitis].

T Werfel1

  • 1Abteilung Immundermatologie und experimentelle Allergologie, Klinik für Dermatologie und Venerologie der Medizinischen Hochschule Hannover. werfel.thomas@mh-hannover.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|September 23, 2009
PubMed
Summary

Oral probiotics show no benefit for treating atopic dermatitis. While one study suggested prevention benefits, results were inconsistent, and current guidelines do not recommend their use.

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Area of Science:

  • Immunology
  • Microbiology
  • Dermatology

Context:

  • Atopic dermatitis (AD) is a common inflammatory skin condition.
  • Probiotics are live microorganisms intended to provide health benefits when consumed or applied topically.
  • Previous research suggested potential benefits of oral probiotics for AD based on theoretical grounds and animal studies.

Purpose:

  • To evaluate the efficacy of orally administered probiotics in the prevention and therapy of atopic dermatitis.
  • To synthesize current clinical evidence regarding probiotic use for AD.

Summary:

  • Current clinical evidence indicates that oral probiotics are not effective for treating mild, moderate, or severe atopic dermatitis.
  • A notable prevention study involving lactobacilli showed positive effects in mothers and newborns, but these findings were not consistently replicated by other researchers.
  • Due to inconsistent results and lack of reproducibility, recommendations for using oral probiotics to prevent atopic dermatitis cannot be made.

Impact:

  • The findings underscore the need for further research to clarify the role of probiotics in atopic dermatitis management.
  • Current guidelines, such as the German S3 guideline on allergy prevention, do not recommend oral probiotics for AD prevention.
  • This evidence challenges the widespread use of probiotics for atopic dermatitis and highlights the importance of evidence-based recommendations.