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Updated: Jun 20, 2026
Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
Published on: October 13, 2023
[Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion]
Wei-Jian Bei1, An-Long Xu, Chu-Yuan Li
1Guangzhou Pharmaceutical University, The Institute of Chinese Medicinal Sciences, Guangzhou 510006, China. bei-wj2000@yahoo.com.cn
Objective:
To investigate the effects of flavonoids from the leaves of Diospyros kaki L (FLDK) on the adhesion between the lymphocyte and the neurone.
Methods:
Centrifugal assay for fluorescence-bsaed cell adhesion was used to assay the adhesion between the lymphocyte and the dorsal root ganglion (DRG).
Results:
The adhesion was significantly suppressed in the presence of FLDK dose-dependently at 5, 25 microg/mL concentration. FLDK was also effective to inhibit the adhesion under the challenge of ICAM-1 by 28.5% and 50.1%, respectively. Furthermore, FLDK enforced the inhibition of anti-NCAM antibody on the lymphocyte adhesion to DRG cells.
Conclusion:
FLDK might contribute to the prevention and treatment of the inflammation injury under neuron insult such as ischemia/reperfusion, neurotrauma and other neurodegenerative disease by inhibiting the adhesion between lymphocytes and neurons.
