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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

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Updated: Jun 20, 2026

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
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Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

High-resolution ocular imaging: combining advanced optics and microtechnology.

M Francesca Cordeiro1, Robert Nickells, Wolfgang Drexler

  • 1UCL Institute of Ophthalmology and Western Eye Hospital, London, United Kingdom.

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
|September 24, 2009
PubMed
Summary
This summary is machine-generated.

Advanced imaging technologies offer new ways to study retinal ganglion cell disorders like glaucoma. These high-resolution techniques provide in vivo access to retinal layers, aiding in early detection and assessment.

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Cell Biology

Background:

  • Retinal ganglion cell disorders, particularly glaucoma, pose significant challenges for diagnosis and monitoring.
  • Current imaging methods have limitations in visualizing the delicate retinal structures with high resolution.
  • Advances in optics, microtechnology, and nanotechnology are driving innovation in ocular imaging.

Purpose of the Study:

  • To summarize current and investigational high-resolution imaging technologies for assessing retinal ganglion cell disorders.
  • To explore the potential applications of these advanced imaging modalities in the diagnosis and management of glaucoma.
  • To document the discussions from the Optic Nerve Rescue and Restoration Think Tank focused on advanced ocular imaging.

Main Methods:

  • Review of currently available and investigational high-resolution imaging technologies.
  • Discussion of the use of various light properties to differentiate cellular structures in vivo.
  • Synthesis of information presented at a specialized think tank on advanced optics, microtechnology, and nanotechnology for eye imaging.

Main Results:

  • High-resolution imaging technologies enable unprecedented in vivo access to retinal layers.
  • Different imaging modalities utilize diverse optical properties for cellular structure differentiation.
  • These technologies hold significant promise for the assessment of glaucoma and other retinal ganglion cell disorders.

Conclusions:

  • Advanced imaging technologies are revolutionizing the study of retinal ganglion cell disorders.
  • High-resolution in vivo imaging is crucial for the early detection and management of glaucoma.
  • Continued development in optics and nanotechnology will further enhance ocular imaging capabilities.