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[Oxidized fibrinogen and its relationship with hemostasis disturbances and endothelial dysfunction during coronary

Iu I Ragino, V A Baum, Ia V Polonskaia

    Kardiologiia
    |September 24, 2009
    PubMed

    Insights

    Oxidized fibrinogen is significantly higher in men with acute myocardial infarction (MI). This finding links fibrinogen oxidation to cardiovascular disease risk and thrombosis.

    Area of Science:

    • Biochemistry
    • Cardiovascular Medicine
    • Hematology

    Background:

    • Oxidative stress plays a role in cardiovascular diseases.
    • Fibrinogen is a key protein in blood coagulation.
    • Understanding fibrinogen modification in myocardial infarction (MI) is crucial.

    Purpose of the Study:

    • To investigate the levels of oxidized fibrinogen in men with acute myocardial infarction (MI).
    • To explore the association between oxidized fibrinogen and markers of thrombosis and endothelial dysfunction.

    Main Methods:

    • Quantification of oxidized fibrinogen levels.
    • Measurement of plasma lipid peroxidation products.
    • Assessment of Willebrand factor and fibrin degradation products.
    • Evaluation of leukocyte-platelet aggregation and nitric oxide (NO) metabolites.

    Main Results:

    • Oxidized fibrinogen was highest in men with acute MI compared to controls.
    • Increased oxidized fibrinogen correlated with markers of lipid peroxidation, coagulation, and platelet aggregation.
    • A decrease in plasma NO metabolites was observed with higher oxidized fibrinogen levels.

    Conclusions:

    • Elevated oxidized fibrinogen is associated with acute myocardial infarction.
    • Oxidized fibrinogen is linked to pro-thrombotic states and endothelial dysfunction.
    • Fibrinogen oxidation may serve as a biomarker for cardiovascular risk.

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