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Nickel in intercellular fluid. Comparison between nickel-allergic patients and controls
I Bonde1, H I Beck, P J Jørgensen
1Department of Environmental Medicine, Odense University, Denmark.
Acta Dermato-Venereologica
|January 1, 1990
Summary
Women with nickel allergy show lower nickel levels in skin blister fluid compared to controls. This suggests that nickel allergy may affect how the body processes nickel.
Area of Science:
- Dermatology
- Toxicology
- Environmental Health
Background:
- Nickel allergy is a common cause of allergic contact dermatitis.
- Understanding nickel kinetics in sensitized individuals is crucial for managing the condition.
Purpose of the Study:
- To investigate nickel concentrations in intercellular fluid and urine of women with nickel allergy compared to controls.
- To explore the relationship between nickel exposure, fluid intake, and nickel levels in sensitized individuals.
Main Methods:
- Recruitment of 12 non-atopic women with nickel allergy and matched controls.
- Collection of intercellular fluid via suction blister technique for nickel analysis.
- Analysis of dietary nickel intake and fluid consumption.
- Collection and analysis of morning urine samples for nickel concentration.
Main Results:
- Median nickel concentration in intercellular fluid was significantly lower in patients (16 nmol/l) than controls (39 nmol/l) (p < 0.02).
- Dietary nickel intake was similar between groups, but fluid intake was higher in controls.
- No significant difference in urinary nickel concentrations was observed between the patient and control groups.
Conclusions:
- Lower nickel levels in blister fluid suggest increased cellular uptake in nickel-sensitized individuals.
- Cellular nickel uptake may influence the body's nickel kinetics, impacting allergic contact dermatitis.
- Further research is needed to elucidate the mechanisms of nickel handling in allergy.