Related Experiment Video
Updated: Jun 20, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Methotrexate information booklet study 2008.
A Mohammad1, A Kilcoyne, U Bond
1Department of Rheumatology, South Infirmary Victoria University Hospital, Cork, Ireland. ausafmohammad@gmail.com
The methotrexate information booklet significantly improved patient understanding of treatment, folic acid, and monitoring. Patients receiving the booklet demonstrated better knowledge of medication, side effects, and necessary precautions.
Area of Science:
- Rheumatology
- Patient Education
- Clinical Trials
Background:
- Assessing the efficacy of patient education materials is crucial in rheumatology.
- Methotrexate (MTX) is a common medication requiring patient comprehension for optimal adherence and safety.
Purpose of the Study:
- To evaluate the impact of a methotrexate information booklet on patient understanding.
- To compare knowledge levels between patients receiving standard care versus those with an educational intervention.
Main Methods:
- A single-blind, prospective controlled trial was conducted with patients in two rheumatology services.
- Participants were divided into an active arm (n=40) using the MTX booklet and a control arm (n=38) without it.
- Patient interviews were conducted over six months using a standardized MTX questionnaire.
Main Results:
- 100% of the active-arm patients understood why they were taking folic acid, compared to 26% in the control arm.
- 88% in the active arm understood the necessity of monthly blood tests versus 47% in the control arm.
- Active-arm patients showed significantly higher awareness of contraception needs (100% vs. 60%) and MTX side effects (100% vs. 40%) compared to controls.
Conclusions:
- The methotrexate information booklet effectively enhanced patient comprehension of their treatment.
- Educational interventions are valuable tools for improving patient knowledge in rheumatology settings.
- Improved patient understanding can lead to better treatment adherence and outcomes.
Related Concept Videos
Therapeutic Drug Monitoring: Affecting Factors
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Antiprotozoal Agents