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Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Related Experiment Video

Updated: Jun 20, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
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Published on: May 10, 2024

Methotrexate information booklet study 2008.

A Mohammad1, A Kilcoyne, U Bond

  • 1Department of Rheumatology, South Infirmary Victoria University Hospital, Cork, Ireland. ausafmohammad@gmail.com

Clinical and Experimental Rheumatology
|September 24, 2009
PubMed
Summary
This summary is machine-generated.

The methotrexate information booklet significantly improved patient understanding of treatment, folic acid, and monitoring. Patients receiving the booklet demonstrated better knowledge of medication, side effects, and necessary precautions.

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Published on: May 10, 2024

Area of Science:

  • Rheumatology
  • Patient Education
  • Clinical Trials

Background:

  • Assessing the efficacy of patient education materials is crucial in rheumatology.
  • Methotrexate (MTX) is a common medication requiring patient comprehension for optimal adherence and safety.

Purpose of the Study:

  • To evaluate the impact of a methotrexate information booklet on patient understanding.
  • To compare knowledge levels between patients receiving standard care versus those with an educational intervention.

Main Methods:

  • A single-blind, prospective controlled trial was conducted with patients in two rheumatology services.
  • Participants were divided into an active arm (n=40) using the MTX booklet and a control arm (n=38) without it.
  • Patient interviews were conducted over six months using a standardized MTX questionnaire.

Main Results:

  • 100% of the active-arm patients understood why they were taking folic acid, compared to 26% in the control arm.
  • 88% in the active arm understood the necessity of monthly blood tests versus 47% in the control arm.
  • Active-arm patients showed significantly higher awareness of contraception needs (100% vs. 60%) and MTX side effects (100% vs. 40%) compared to controls.

Conclusions:

  • The methotrexate information booklet effectively enhanced patient comprehension of their treatment.
  • Educational interventions are valuable tools for improving patient knowledge in rheumatology settings.
  • Improved patient understanding can lead to better treatment adherence and outcomes.