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Breast cancer during pregnancy
Edouard Vinatier1, Benjamin Merlot, Edouard Poncelet
1Service de Chirurgie Gynécologique, Hôpital Jeanne de Flandre, 59037 Lille cedex, France.
European Journal of Obstetrics, Gynecology, and Reproductive Biology
|September 24, 2009
Summary
Breast cancer during pregnancy is rare but requires prompt diagnosis and tailored treatment. Management involves surgery anytime, chemotherapy after the first trimester, and delaying radiation or endocrine therapies until postpartum.
Area of Science:
- Oncology
- Maternal-Fetal Medicine
Background:
- Breast cancer in pregnancy presents unique diagnostic and therapeutic challenges.
- Limited prospective studies exist for managing breast cancer during gestation.
- Pregnancy-associated breast cancer (PABC) shares disease characteristics with age-matched controls.
Purpose of the Study:
- To review the diagnosis and treatment of breast cancer in pregnant women.
- To provide guidance on managing PABC based on current evidence.
Main Methods:
- Literature review of prospective studies and case series on PABC.
- Analysis of diagnostic limitations and treatment options during pregnancy.
- Synthesis of evidence regarding surgical, chemotherapeutic, and radiation approaches.
Main Results:
- Diagnosis of PABC may have staging limitations.
- Surgical interventions are feasible and comparable to non-pregnant patients.
- Chemotherapy is permissible after the first trimester.
- Radiotherapy and endocrine/antibody treatments should be deferred until after delivery.
Conclusions:
- Aggressive workup of breast symptoms in pregnant women is crucial for early PABC diagnosis.
- Multidisciplinary treatment planning is essential for optimal outcomes.
- Treatment strategies must balance maternal health and fetal safety, adapting standard protocols for pregnancy.
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