Related Experiment Video
Updated: Jun 20, 2026
08:47
Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
Published on: May 1, 2020
c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: implications for anticancer therapy.
Chen-Ju Lin1, Abba Malina, Jerry Pelletier
1Department of Biochemistry and McGill Cancer Center, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada.
Cancer Research
|September 24, 2009
Summary
The Myc and eukaryotic initiation factor 4F (4F) complex regulate cell growth and cancer. Myc increases 4F activity, driving cell transformation, suggesting therapeutic inhibition for cancer treatment.
Area of Science:
- Molecular biology
- Cellular biology
- Oncology
Background:
- The Myc/Max/Mad transcription factors and eukaryotic initiation factor 4F (4F) complex are crucial for cell growth, proliferation, differentiation, and oncogenesis.
- Myc's role in cell growth and proliferation is increasingly linked to enhanced eIF4F activity.
Purpose of the Study:
- To elucidate the molecular mechanisms underlying Myc-driven cell transformation.
- To explore the potential of targeting Myc and/or eIF4F for cancer therapy.
Main Methods:
- This study integrates findings from molecular and cellular biology research.
- The research focuses on the regulatory relationship between Myc and eIF4F activity.
Main Results:
- A feedforward relationship exists where Myc enhances eIF4F activity, contributing to cell transformation.
- This interplay provides a potential molecular basis for Myc's oncogenic functions.
Conclusions:
- Targeting the Myc/eIF4F pathway presents a promising therapeutic strategy for various human cancers.
- Inhibiting eIF4F and/or Myc could offer novel treatments for oncological conditions.
Related Concept Videos
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...