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Borderline Personality Disorder

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
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Personality Disorders: Paranoid and Schizoid

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Personality Disorders: Dependent and Obsessive-Compulsive

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Related Experiment Video

Updated: Jun 20, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Borderline personality disorder: toward integration.

¹Department of Psychiatry and Mental Health, University of Cape Town, South Africa.

|September 24, 2009

Summary

This summary is machine-generated.

Borderline personality disorder (BPD) involves emotional dysregulation and impulse control issues, linked to attachment disruptions and altered brain activity. Treatment integrates psychotherapy and potentially medication targeting key neurotransmitter systems.

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Area of Science:

Neuroscience
Psychiatry
Clinical Psychology

Background:

Borderline personality disorder (BPD) is marked by emotional dysregulation and impulse control deficits.
Symptoms are associated with attachment disruptions and distorted self/other processing.
Neurobiological underpinnings involve prefrontal-amygdala circuitry and neurotransmitter systems.

Observation:

Patients with BPD exhibit prefrontal hypoactivity and amygdala hyperreactivity.
Alterations in prefrontal-limbic interactions are observed.
Dysregulation impacts cognitive-affective processing of self and others.

Findings:

Key molecular pathways implicated include serotonergic, noradrenergic, and dopaminergic systems.
Pharmacotherapy targeting these systems shows potential utility.
Psychotherapy is the cornerstone of BPD management.

Implications:

Understanding neurocircuitry aids in developing targeted treatments for BPD.
Pharmacological interventions may complement psychotherapy.
A strong therapeutic alliance is vital for effective BPD management.