Related Experiment Video
Updated: Jun 20, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
Published on: March 20, 2018
Binding fullerenol C(60)(OH)(24) to dsDNA
Mariana Pinteala1, Andrei Dascalu, Cezar Ungurenasu
1Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica, 700487 Iasi, Romania.
Abstract:
The first C(60)(OH)(24)-DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C(60)(OH)(24) is in proportion to the concentration of DNA in the range of 1 x 10(-9) to 8 x 10(-5) molL(-1) and the detection limit was 1.3 ng mL(-1). Fullerenol C(60)(OH)(24) binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA.
Related Concept Videos
Single-Strand DNA Binding Proteins
DNA Damage Can Stall the Cell Cycle
DNA Damage can Stall the Cell Cycle
Long-patch Base Excision Repair
S-Cdk Initiates DNA Replication
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...

