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Updated: Jun 20, 2026

Whole Mount Labeling of Cilia in the Main Olfactory System of Mice
Published on: December 27, 2014
Identification of Cl(Ca) channel distributions in olfactory cilia
Dorjsuren Badamdorj1, David A Edwards, Donald A French
1Department of Mathematical Sciences, University of Delaware, Newark, DE 19716, U.S.A.
Abstract:
Identification of detailed features of neuronal systems is an important challenge in the biosciences today. Transduction of an odor into an electrical signal occurs in the membranes of the cilia. The Cl(Ca) channels that reside in the ciliary membrane are activated by calcium, allow a depolarizing efflux of Cl(-) and are thought to amplify the electrical signal to the brain.In this paper, a mathematical model consisting of partial differential equations is developed to study two different experiments; one involving the interaction of the cyclic-nucleotide-gated (CNG) and Cl(Ca) channels and the other, the diffusion of Ca(2+) into cilia. This work builds on an earlier study (Mathematical modeling of the Cl(Ca) ion channels in frog olfactory cilia. Ph.D. Thesis, University of Cincinnati, Cincinnati, OH, 2006; Math. Comput. Modelling 2006; 43:945-956; Biophys. J. 2006; 91:179-188), which suggested that the CNG channels are clustered at about 0.28 of the length of a cilium from its open end. Closed-form solutions are derived after certain reductions in the model are made. These special solutions provide estimates of the channel distributions. Scientific computation is also used. This preliminary study suggests that the Cl(Ca) ion channels are also clustered at about one-third of the length of a cilium from its open end.
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