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Published on: June 10, 2025
[Post-hospital mortality in patients re-admitted due to COPD. Utility of BODE index]
M Sanjaume1, P Almagro, M Rodríguez-Carballeira
1Servicio de Medicina Interna, Hospital Mutua de Terrassa, Terrassa, Barcelona, España. mariasanjaume@hotmail.com
Insights
The BODE index accurately predicts mortality in hospitalized patients with Chronic Obstructive Pulmonary Disease (COPD) exacerbations. This tool is reliable for assessing survival risk in COPD patients requiring multiple hospital admissions.
Area of Science:
- Pulmonary Medicine
- Critical Care Medicine
Context:
- The BODE index is established for predicting mortality in ambulatory Chronic Obstructive Pulmonary Disease (COPD) patients.
- Its predictive value in hospitalized COPD patients with acute exacerbations remains largely uncharacterized.
Purpose:
- To prospectively evaluate the utility of the BODE index in predicting mortality among hospitalized patients experiencing acute exacerbations of COPD.
Summary:
- This study assessed 66 patients hospitalized for COPD exacerbations. The BODE index, calculated at discharge, was evaluated alongside other clinical factors.
- Higher mortality was associated with older age, comorbidities, and worse BODE index scores. Hypercapnia and the BODE index emerged as independent predictors of mortality in multivariate analysis.
Impact:
- The BODE index, when measured at hospital discharge, serves as an accurate and dependable prognostic tool for mortality in COPD patients with recurrent acute exacerbations.
- Findings support the use of the BODE index for risk stratification and management decisions in this vulnerable patient population.
Background:
The BODE index can accurately predict mortality in ambulatory patients with COPD, although its utility in hospitalized patients is unknown.
Material And Methods:
We prospectively evaluated all patients hospitalized during one year for acute exacerbation of COPD with one or more admissions in the previous year. On discharge, previous functional dependence, comorbidity, depression and quality of life, among other variables, were evaluated. Body mass index, 6-minute walking test, dyspnea scale and spirometry with a post-bronchodilator test were performed on the last day of hospitalization and the BODE index was calculated using these data.
Results:
A total of 66 patients were included, with a mean age of 71.6 +/- 8.9 years. Of these patients, 42 (63.6%) died before the end of the study (median follow-up 1,490 days). A higher mortality was observed among the oldest patients (p < 0.004), those with more comorbidities (p < 0.05), worse score on the BODE index (p < 0.006; OR 1.3; CI 95%: 1.07-1.54) and the dyspnea scale (p < 0.008). Functional dependence (p < 0.02), and pCO2 > 45 mmHg at discharge (p < 0.001) were also significant predictors of mortality. In the multivariate analysis, only hypercapnia (p < 0.004; OR 3.48; CI 95% 1.49-8.14) and the BODE index (p < 0.0005; OR 1.47; CI 95%: 1.18-1.82) were independent predictors of mortality.
Conclusions:
The BODE index measured at hospital discharge is an accurate and reliable predictor of mortality in patients who require several admissions for acute exacerbations of COPD.
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