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Related Experiment Videos

Innervation of bladder and bowel.

G Burnstock1

  • 1Department of Anatomy and Developmental Biology, University College London, UK.

Ciba Foundation Symposium
|January 1, 1990
PubMed
Summary

This study details autonomic nerve function in the bladder and bowel, explaining neurotransmission and neural coding. It covers innervation patterns and changes due to aging and disease.

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Urology

Background:

  • The autonomic nervous system controls visceral functions, including bladder and bowel activity.
  • Understanding the neuromuscular junction is crucial for explaining gut and bladder physiology.

Purpose of the Study:

  • To define neurotransmission, co-transmission, and neuromodulation at the autonomic neuromuscular junction.
  • To describe the chemical coding and innervation patterns of the bladder and bowel.
  • To discuss changes in innervation during development, aging, and disease.

Main Methods:

  • Review of existing literature on autonomic innervation.
  • Analysis of neurotransmitter roles (co-transmission, neuromodulation).
  • Description of neural pathways and receptor expression.

Main Results:

  • Detailed mapping of sympathetic, parasympathetic, sensory-motor, and intrinsic neuronal innervation.
  • Functional and pharmacological characterization of bladder, bowel, urethral, and anal sphincter innervation.
  • Identification of alterations in innervation patterns with age and disease.

Conclusions:

  • Autonomic innervation is complex, involving diverse neurotransmitters and precise neural coding.
  • Innervation patterns are dynamic, adapting to physiological and pathological conditions.
  • This knowledge is vital for understanding and treating bladder and bowel dysfunction.

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